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David Twesigomwe, Britt I Drögemöller, Galen EB Wright, Azra Siddiqui, Jorge da Rocha, Zané Lombard, Scott Hazelhurst.
StellarPGx: A Nextflow pipeline for calling star alleles in cytochrome P450 genes.
Clinical Pharmacology & Therapeutics,
2021.
Jorge da Rocha, Houcemeddine Othman, Gerrit Botha, David Twesigomwe, Samah Ahmed, Laura Cottino, Britt Drögemolller, Faisal Fadlelmola, Philip Machanick, Mamana Mbiyavanga, others.
The extent and impact of variation in ADME genes in sub-Saharan African populations.
bioRxiv,
2020.
Wan-Chun Chang, Riichiro Abe, Paul Anderson, Wanpen Anderson, Michael R Ardern-Jones, Thomas M Beachkofsky, Teresa Bellón, Agnieszka K Biala, Charles Bouchard, Gianpiero L Cavalleri, others.
SJS/TEN 2019: From science to translation.
Journal of dermatological science,
2020.
Galen EB Wright, Hailey Findlay Black, Jennifer A Collins, Terence Gall-Duncan, Nicholas S Caron, Christopher E Pearson, Michael R Hayden.
Interrupting sequence variants and age of onset in Huntington's disease: clinical implications and emerging therapies.
The Lancet Neurology,
2020.
Galen EB Wright, Nicholas S Caron, Bernard Ng, Lorenzo Casal, William Casazza, Xiaohong Xu, Jolene Ooi, Mahmoud A Pouladi, Sara Mostafavi, Colin JD Ross, others.
Gene expression profiles complement the analysis of genomic modifiers of the clinical onset of Huntington disease.
Human molecular genetics,
2020.
Hailey Findlay Black, Galen EB Wright, Jennifer A Collins, Nicholas Caron, Chris Kay, Qingwen Xia, Larissa Arning, Emilia K Bijlsma, Ferdinando Squitieri, Huu Phuc Nguyen, others.
Frequency of the loss of CAA interruption in the HTT CAG tract and implications for Huntington disease in the reduced penetrance range.
Genetics in Medicine,
2020.
David Twesigomwe, Galen EB Wright, Britt I Drögemöller, Jorge da Rocha, Zané Lombard, Scott Hazelhurst.
A systematic comparison of pharmacogene star allele calling bioinformatics algorithms: a focus on CYP2D6 genotyping.
NPJ genomic medicine,
2020.
Britt I Drögemöller, Galen EB Wright, Cody Lo, Tan Le, Beth Brooks, Amit P Bhavsar, Shahrad R Rassekh, Colin JD Ross, Bruce C Carleton.
Pharmacogenomics of Cisplatin-Induced Ototoxicity: Successes, Shortcomings and Future Avenues of Research.
Clinical Pharmacology & Therapeutics,
2019.
Zulfan Zazuli, Leila S Otten, Britt I Drögemöller, Mara Medeiros, Jose G Monzon, Galen EB Wright, Christian K Kollmannsberger, Philippe L Bedard, Zhuo Chen, Karen A Gelmon, others.
Outcome Definition Influences the Relationship Between Genetic Polymorphisms of ERCC1, ERCC2, SLC22A2 and Cisplatin Nephrotoxicity in Adult Testicular Cancer Patients.
Genes,
2019.
Galen EB Wright, Jennifer A Collins, Chris Kay, Cassandra McDonald, Egor Dolzhenko, Qingwen Xia, Kristina Bečanović, Britt I Drögemöller, Alicia Semaka, Charlotte M Nguyen, others.
Length of uninterrupted CAG, independent of polyglutamine size, results in increased somatic instability, hastening onset of Huntington disease.
The American Journal of Human Genetics,
2019.
Galen EB Wright, Jennifer A. Collins, Chris Kay, Cassandra McDonald, Egor Dolzhenko, Qingwen Xia, Kristina Bečanović, Alicia Semaka, Charlotte M. Nguyen, Brett Trost, Fiona Richards, Emilia K. Bijlsma, Ferdinando Squitieri, Stephen W. Scherer, Michael A. Eberle, Ryan K.C. Yuen, Michael R. Hayden.
Length of uninterrupted CAG repeats, independent of polyglutamine size, results in increased somatic instability and hastened age of onset in Huntington disease.
bioRxiv,
2019.
André BP van Kuilenburg, Maja Tarailo-Graovac, Phillip A Richmond, Britt I Drögemöller, Mahmoud A Pouladi, René Leen, Koroboshka Brand-Arzamendi, Doreen Dobritzsch, Egor Dolzhenko, Michael A Eberle, others.
Glutaminase Deficiency Caused by Short Tandem Repeat Expansion in GLS.
New England Journal of Medicine,
2019.
Galen EB Wright, Britt I Drögemöller, Colin JD Ross, Bruce C Carleton.
Genome-Wide Association Studies of Drug-Induced Liver Injury Make Progress Beyond the HLA Region.
Gastroenterology,
2019.
Galen E.B. Wright, Nicholas S. Caron, Bernard Ng, Lorenzo Casal, Xiaohong Xu, Jolene Ooi, Mahmoud A Pouladi, Sara Mostafavi, Colin J.D. Ross, Michael R. Hayden.
Gene expression profiles complement the analysis of genomic modifiers of the clinical onset of Huntington disease.
bioRxiv,
2019.
Chris Kay, Jennifer A Collins, Galen EB Wright, Fiona Baine, Zosia Miedzybrodzka, Folefac Aminkeng, Alicia J Semaka, Cassandra McDonald, Mark Davidson, Steven J Madore, others.
The molecular epidemiology of Huntington disease is related to intermediate allele frequency and haplotype in the general population.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics,
2018.
Galen EB Wright, Ursula Amstutz, Britt I Drögemöller, Joanne Shih, Shahrad R Rassekh, Michael R Hayden, Bruce C Carleton, Colin JD Ross, Canadian Pharmacogenomics Network for Drug Safety Consortium.
Pharmacogenomics of vincristine-induced peripheral neuropathy implicates pharmacokinetic and inherited neuropathy genes.
Clinical Pharmacology & Therapeutics,
2018.
Mark McCormack, Hongsheng Gui, Andrés Ingason, Doug Speed, Galen EB Wright, Eunice J Zhang, Rodrigo Secolin, Clarissa Yasuda, Maxwell Kwok, Stefan Wolking, others.
Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients.
Neurology,
2018.
Britt I Drögemöller, Beth Brooks, Jose G Monzon, Galen EB Wright, Geoffrey Liu, Daniel J Renouf, Christian Kollmannsberger, Phillipe L Bedard, Michael R Hayden, Karen A Gelmon, others.
Further investigation of the role of ACYP2 and WFS1 pharmacogenomic variants in the development of cisplatin-induced ototoxicity in testicular cancer patients.
Clinical Cancer Research,
2018.
Kaarina Kowalec*, Galen EB Wright*, Britt I Drögemöller, Folefac Aminkeng, Amit P Bhavsar, Elaine Kingwell, Eric M Yoshida, Anthony Traboulsee, Ruth Ann Marrie, Marcelo Kremenchutzky, others, *Authors contributed equally to this work.
Common variation near IRF6 is associated with IFN-beta-induced liver injury in multiple sclerosis.
Nature Genetics,
2018.
Britt I Drögemöller*, Galen EB Wright*, Joanne Shih, Jose G Monzon, Karen A Gelmon, Colin JD Ross, Ursula Amstutz, Bruce C Carleton, others, *Authors contributed equally to this work.
CYP2D6 as a treatment decision aid for ER-positive non-metastatic breast cancer patients: a systematic review with accompanying clinical practice guidelines.
Breast Cancer Research and Treatment,
2018.
Reo Tanoshima, Amna Khan, Agnieszka K Biala, Jessica N Trueman, Britt I Drögemöller, Galen EB Wright, Jafar S Hasbullah, Gabriella SS Groeneweg, Colin JD Ross, Bruce C Carleton, others.
Analyses of Adverse Drug Reactions - Nationwide Active Surveillance Network: Canadian Pharmacogenomics Network for Drug Safety Database.
The Journal of Clinical Pharmacology,
2018.
hackseq Organizing Committee, others.
hackseq: Catalyzing collaboration between biological and computational scientists via hackathon.
F1000Research,
2017.
Chris Kay, Indira Tirado-Hurtado, Mario Cornejo-Olivas, Jennifer A Collins, Galen Wright, Miguel Inca-Martinez, Diego Veliz-Otani, Maria E Ketelaar, Ramy A Slama, Colin J Ross, others.
The targetable A1 Huntington disease haplotype has distinct Amerindian and European origins in Latin America.
European Journal of Human Genetics,
2017.
Britt I Drögemöller, Jose G Monzon, Amit P Bhavsar, Adrienne E Borrie, Beth Brooks, Galen EB Wright, Geoffrey Liu, Daniel J Renouf, Christian K Kollmannsberger, Philippe L Bedard, others.
Association between SLC16A5 genetic variation and cisplatin-induced ototoxic effects in adult patients with testicular cancer.
JAMA Oncology,
2017.
Britt I Drögemöller, Robin Emsley, Bonginkosi Chiliza, Lize van der Merwe, Galen EB Wright, Michelle Daya, Eileen Hoal, Anil K Malhotra, Todd Lencz, Delbert G Robinson, others.
The identification of novel genetic variants associated with antipsychotic treatment response outcomes in first-episode schizophrenia patients.
Pharmacogenetics and Genomics,
2016.
GEB Wright, B Carleton, MR Hayden, CJD Ross.
The global spectrum of protein-coding pharmacogenomic diversity.
The Pharmacogenomics Journal,
2016.
Zhe Wang, A Dessa Sadovnick, Anthony L Traboulsee, Jay P Ross, Cecily Q Bernales, Mary Encarnacion, Irene M Yee, Madonna de Lemos, Talitha Greenwood, Joshua D Lee, others.
Nuclear receptor NR1H3 in familial multiple sclerosis.
Neuron,
2016.
Zhe Wang, A Dessa Sadovnick, Anthony L Traboulsee, Jay P Ross, Cecily Q Bernales, Mary Encarnacion, Irene M Yee, Madonna de Lemos, Talitha Greenwood, Joshua D Lee, others.
Case-control studies are not familial studies.
Neuron,
2016.
Carola R Röhrich, Britt I Drögemöller, Ogechi Ikediobi, Lize van der Merwe, Nelis Grobbelaar, Galen EB Wright, Nathaniel McGregor, Louise Warnich.
CYP2B6* 6 and CYP2B6* 18 predict long-term efavirenz exposure measured in hair samples in HIV-positive South African women.
AIDS Research and Human Retroviruses,
2016.
GEB Wright.
Warfarin pharmacogenetics in the era of new oral anticoagulants.
Clinical Genetics,
2015.
GEB Wright.
Genomic study of congenital insensitivity to pain provides new avenues for the development of analgesics.
Clinical Genetics,
2015.
Tyren M Dodgen, Britt I Drögemöller, Galen EB Wright, Louise Warnich, Francois E Steffens, A Duncan Cromarty, Marco Alessandrini, Michael S Pepper.
Evaluation of predictive CYP2C19 genotyping assays relative to measured phenotype in a South African cohort.
Pharmacogenomics,
2015.
Jason Bosch, Jean Jacques N Noubiap, Collet Dandara, Nomlindo Makubalo, Galen Wright, Jean-Baka Domelevo Entfellner, Nicki Tiffin, Ambroise Wonkam.
Sequencing of GJB2 in Cameroonians and Black South Africans and comparison to 1000 Genomes Project data support need to revise strategy for discovery of nonsyndromic deafness genes in Africans.
Omics: A Journal of Integrative Biology,
2014.
Britt I Drogemöller, Dana JH Niehaus, Bonginkosi Chiliza, Lize van der Merwe, Laila Asmal, Anil K Malhotra, Galen EB Wright, Robin Emsley, Louise Warnich.
Patterns of variation influencing antipsychotic treatment outcomes in South African first-episode schizophrenia patients.
Pharmacogenomics,
2014.
Galen EB Wright, Adebowale A Adeyemo, Nicki Tiffin.
Informed consent and ethical re-use of African genomic data.
Human Genomics,
2014.
Britt I Drögemöller, Galen EB Wright, Louise Warnich.
Considerations for rare variants in drug metabolism genes and the clinical implications.
Expert Opinion on Drug Metabolism & Toxicology,
2014.
Britt I Drögemöller, Galen EB Wright, Dana JH Niehaus, Robin Emsley, Louise Warnich.
Next-generation sequencing of pharmacogenes: a critical analysis focusing on schizophrenia treatment.
Pharmacogenetics and Genomics,
2013.
Tyren M Dodgen, Warren E Hochfeld, Heidi Fickl, Sahle M Asfaha, Chrisna Durandt, Paul Rheeder, Britt I Drögemöller, Galen EB Wright, Louise Warnich, Christiaan DJ Labuschagne, others.
Introduction of the AmpliChip CYP450 Test to a South African cohort: a platform comparative prospective cohort study.
BMC Medical Genetics,
2013.
Galen EB Wright, Pieter GJ Koornhof, Adebowale A Adeyemo, Nicki Tiffin.
Ethical and legal implications of whole genome and whole exome sequencing in African populations.
BMC Medical Ethics,
2013.
Britt Ingrid Drögemöller, Marieth Plummer, Lundi Korkie, Gloudi Agenbag, Anke Dunaiski, Dana Niehaus, Liezl Koen, Stefan Gebhardt, Nicol Schneider, Antonel Olckers, others.
Characterization of the genetic variation present in CYP3A4 in three South African populations.
Frontiers in Genetics,
2013.
Vural Özdemir, Erik Fisher, Edward S Dove, Hilary Burton, Galen EB Wright, Mario Masellis, Louise Warnich.
End of the beginning and public health pharmacogenomics: knowledge in 'Mode 2' P5 medicine.
Current Pharmacogenomics and Personalized Medicine,
2012.
Liezl Koen, Dana JH Niehaus, Galen Wright, Louise Warnich, Greetje De Jong, Robin A Emsley, Sumaya Mall.
Chromosome 22q11 in a Xhosa schizophrenia population.
SAMJ: South African Medical Journal,
2012.
Galen EB Wright, Dana JH Niehaus, Lize van der Merwe, Liezl Koen, Lundi J Korkie, Craig J Kinnear, Britt I Drögemöller, Louise Warnich.
Association of MB-COMT polymorphisms with schizophrenia-susceptibility and symptom severity in an African cohort.
Progress in Neuro-Psychopharmacology and Biological Psychiatry,
2012.
Britt I Drögemöller, Galen EB Wright, Dana JH Niehaus, Robin A Emsley, Louise Warnich.
Whole-genome resequencing in pharmacogenomics: moving away from past disparities to globally representative applications.
Pharmacogenomics,
2011.
GEB Wright, DJH Niehaus, L Koen, BI Drögemöller, L Warnich.
Psychiatric genetics in South Africa: cutting a rough diamond.
African Journal of Psychiatry,
2011.
Louise Warnich, Britt I Drogemoller, Michael S Pepper, Collet Dandara, Galen EB Wright.
Pharmacogenomic research in South Africa: lessons learned and future opportunities in the rainbow nation.
Current Pharmacogenomics and Personalized Medicine,
2011.
Galen EB Wright, Dana JH Niehaus, Britt I Drögemöller, Liezl Koen, Andrea Gaedigk, Louise Warnich.
Elucidation of CYP2D6 genetic diversity in a unique African population: implications for the future application of pharmacogenetics in the Xhosa population.
Annals of Human Genetics,
2010.
Britt I Drögemöller, Galen EB Wright, Dana JH Niehaus, Liezl Koen, Stefanie Malan, Danielle M Da Silva, Renate Hillermann–Rebello, Anthony M La Grange, Mauritz Venter, Louise Warnich.
Characterization of the genetic profile of CYP2C19 in two South African populations.
Pharmacogenomics,
2010.